產(chǎn)品英文名稱：JAG-1 protein active peptide fragment
產(chǎn)品中文名稱：JAG-1 蛋白活性片斷

JAG-1 protein active peptide fragment產(chǎn)品介紹：
最初是在果蠅神經(jīng)系統(tǒng)發(fā)育的研究中發(fā)現(xiàn)Notch信號途徑的功能。Notch信號通路是進化中高度保守的信號轉(zhuǎn)導通路，其調(diào)控細胞增殖、分化和凋亡的功能幾乎涉及所有組織和器官。該通路由Notch受體、配體和CSL蛋白3部分組成。
Jagged-1是notch 配體的受體，這種肽序列CDDYYYGFGCNKFCRPR能模擬全長Jagged-1的功能，作為激動劑激活Notch 信號通路。
JAG-1 protein active peptide fragment產(chǎn)品純度高，通過RP-HPLC鑒定純度大于95%。

JAG-1 protein active peptide fragment產(chǎn)品英文簡述：
The Notch pathway is an important pathway in stem cell functions. Jagged-1 is a ligand for Notch receptors. This peptide with a sequence of CDDYYYGFGCNKFCRPR has been shown to mimic the function of full-length Jagged-1, and therefore, can be used as an agonist to activate the Notch pathway.
Ref: Nickoloff et al, Cell Death Different, 2002; Sato T et al, Nature, 2009

• Stability：The lyophilized protein is stable for at least 1 year if stored at -80 degree C. Reconstituted protein is stable for at least 1 month at    4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw
• Purity：Greater than 95% as determined by RP-HPLC analysis